Inspired by patients to challenge the status quo
Olema is committed to partnering with patients to develop new, effective therapies for women’s cancers.
We refuse to accept the current standard of care as the best-case scenario for women living with cancer and are optimistic that we can deliver a potential new solution. Across our company and in all we do, Olema is relentlessly focused on creating a better way.
Current Clinical Trials
A Phase 1b Study in Combination With a CDK4/6 Inhibitor or With a PI3K Inhibitor
A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer
OP-1250 is a small molecule Complete Estrogen Receptor Antagonist (CERAN).
This clinical trial is a Phase 1/2, open-label, multi-center, dose-escalation and expansion study evaluating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of daily oral administration of OP-1250.
A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients